XRCC6 monoclonal antibody, clone N3H10
产品名称： XRCC6 monoclonal antibody, clone N3H10
英文名称： XRCC6 monoclonal antibody, clone N3H10
产品编号： MAB1979
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native XRCC6.
- Immunogen:
- Native purified XRCC6 from human placental extract.
- Host:
- Mouse
- Reactivity:
- Clawed frog, Human, Monkey
- Form:
- Liquid
- Isotype:
- IgG2b
- Storage Buffer:
- In PBS (0.08% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Native Purified Protein.
- Recommend Usage:
- Western blot (0.25 to 0.5 ug/mL)
Immunohistochemistry on frozen and formalin to fixed/paraffin to embedded tissues (1 to 2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL-60) cells and lymphocytes undergoing apoptosis.
Ajmani AK, Satoh M, Reap E, Cohen PL, Reeves WH.J Exp Med. 1995 Jun 1;181(6):2049-58.
- 2.
- Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens.
Wang J, Chou CH, Blankson J, Satoh M, Knuth MW, Eisenberg RA, Pisetsky DS, Reeves WH.Mol Biol Rep. 1993 Jun;18(1):15-28.
- 3.
- Purification and characterization of proximal sequence element-binding protein 1, a transcription activating protein related to Ku and TREF that binds the proximal sequence element of the human U1 promoter.
Knuth MW, Gunderson SI, Thompson NE, Strasheim LA, Burgess RR.J Biol Chem. 1990 Oct 15;265(29):17911-20.
- Application Image
- Western Blot
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Immunohistochemistry (Frozen sections)
- Immunofluorescence
- ELISA
- Entrez GeneID:
- 2547
- Gene Name:
- XRCC6
- Gene Alias:
- CTC75,CTCBF,G22P1,KU70,ML8,TLAA
- Gene Description:
- X-ray repair complementing defective repair in Chinese hamster cells 6
- Omim ID:
- 152690
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq
- Other Designations:
- ATP-dependent DNA helicase II, 70 kDa subunit,CTC box binding factor 75 kDa subunit,Ku autoantigen p70 subunit,Ku autoantigen, 70kDa,OTTHUMP00000028581,thyroid autoantigen 70kD (Ku antigen),thyroid autoantigen 70kDa (Ku antigen),thyroid-lupus autoantigen
- Gene Pathway
- Related Disease
- Adenocarcinoma
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Central Nervous System Neoplasms
- Diabetes Mellitus, Type 2
- DNA Damage
- Edema
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Genomic Instability
- Glioma
- Head and Neck Neoplasms
- Kidney Failure, Chronic
- Lung Neoplasms
- Male Urogenital Diseases